GP ana MIL

G Protein
Adrenergic Receptor

• Ligand binds to receptor binds
• Conformation changes throughout the Seven Transmembrane-helix (7TM)receptor

G Protein Coupling

• Gprotein binds to newly changed conformation of 7TM
• Binding to 7TM creates a conformational change (GDP-->GTP) and Gprotein components breaks off
  • Galpha (GTP) breaks off from Gbetagamma
  • GTP seeks target protein

Target Acquisition

• GTP activates target protein
• Hydrolysis of GTP by the alpha subunit inactivates and causes breaking off from the target protein
• GDP seeks Gbetagamma to remain become inactive

Adrenergic Receptor

• Orders are cut and sent and recieved
• Homebase prepares for mission

G Protein Coupling

• Unit (GTP) is mobilized
• Unit is changed to fit mission
• Unit is sent to do mission
• Components of unit break off to their tasks to complete the mission

Target Acquisition

• Mission is completed
• Unit comes back to origin