GA3PDHase

Glycolysis - (GAP) into (1,3BPG)
Enzymes - Enzymes Clinical Significance

Oxidizes Glyceraldehyde 3-phosphate

Oxidoreductases

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH)

• Glyceraldehyde 3-phosphateSubstrate
• Needs NAD+
• Reversible
• Product has a high phosphoryl transfer potential
  • Mixed anhydride of phosphoric acid and carboxilic acid

Coupled RXN Specifics:

• Oxidation of aldehyde to COOH by NAD
  • Farovarble dG(o') -50kJ

Thioester Intermediate - more stable than reactant but less stable tha product

• Joining of COOH and orthophosphate to form acyl-phosphate product
  • Unfavorable

Concepts:

• Redox Chemistry - CHM

Additional Links:

• Wikipedia