FRU 1P Path

Fructose 1-phosphate Pathway

Conversion of Fructose in the liver to be metabolized by Glycolysis

Liver
Fructose

Glycolysis

• Fructose into Fructose 1-phosphate
  • Fructokinase
• Fructose 1-phosphate into 1)Dihydroxyacetone Phosphate (DHAP) and 2)Glyceradehyde
  • Fructose 1-phosphate Aldolase/Aldolase B
  • Mechanism is via the formation of a Schiff Base
    • 1)DHAP goes into stage 2 of Glycolysis
• 2)Glyceraldehyde into Glyceraldehyde 3-phosphate
  • Triose Kinase
    • GAP goes into stage 3 of Glycolysis

Concepts:

• Schiff Base Chemstry]] - OCHM
  • Schiff Base Mechanism