GLC t G6P

[[Glycolysis]]

==Glucose + ATP <-(Hexokinase)-> Glucose 6-phosphate + ADP + H==
[[Hexokinase]]
====Fundamentals:====
*Glucose is transported by specific transport proteins into the cell
*Glucose is phosphorylated by ATP to form Glucose 6-phosphate
**Phosphorylation changes polarity of glucose
***keeps the molecule inside the cell, does now allow the passage out of the membrane
**Phosphoryl groups destabilize glucose
====Specifics====
*Hexokinase has two lobes that move toward each other
*Removal of water form the active site enhances the specificity of the enzyme
*Binding site could attack the gamma phosphoryl group of ATP forming ADP and Pi