PKA

Signal Transduction - beta-Adrenergic Receptor,G Protein, Adenylate cyclase

Transferase activated by cyclic AMP and functions in sugar metabolism

Transferases,cAMP

Protein Kinase A (PKA)

Function/Purpose:

• regulates Phosphorylase Kinase by phosphorylation
• Sugar Metabolism
  • Glycolysis
  • Gluconeogenesis

Fundamentals:

Mechanism:

Adenylate Cyclase (AC)

• Binding of cAMP to regulatory chains releases the catalytic chains
• Activated PKA then phosphorylates Serine and Threonine residues on in many targets to alter their activity

PKA Mechanism

• Phosphorylates Phosphorylase Kinase

Components:

• Two subunits
  • Regulatory chains (R) subunit
  • Catalytic chains (C) subunit
• Four cAMP receptors

Additional Information:

• Wikipedia