Causes alkylation and interchalation
CC-1065
Fundamentals:
- Three subunits
- Active site is the peroxide on the first subunit
- Selectively modifies the DNA on the Adenine N-3
LOC:
- Minor Groove DNA
- Stabilizes bent shape (A-T)
- Streptomyces sp
Mechanism:
- Nucleophilic attack of peroxide pushes electrons south towards the carbonyl
- Interchalation of subunit 1
