Adriamycin

Medications

Undergoes biological reduction, alkylation and interchalation

Adriamycin

Fundamentals:

• Four subunits
  • Anthraquinone antibiotic
• Blocks DNA replication
• Undergoes biological reduction
• L-Daunosamine
• Distinct R group is OH

LOC:

• Minor Groove DNA

Mechanism:

• DNA is the reducing agent
  • L-daunosamine leaves
    • Through resonance
• DNA attacks previous LG position

Concepts:

• Intercalation

Salient Similarities:

• Daunomycin

Additional Information:

• Wikipedia