6.8 mg/dL INC risk
*Immune system engulfs the sodium urate crystals
*Causes inflammation
====Metabolism====
*PRS Mutation Destroys Feedback
Inhibition
**PRS is normally feedback inhibited by [[purine]]
nucleotides
*Ribose 5-phosphate + ATP -(PRS)->
5-phosphoribosyl-1-pyrophosphate + AMP **Phosphoribosylpyrophosphate
syntehtase (PRS): catalyzes the synthesis of phophoribosylpyrophosphate
(PRPP)
**phophoribosylpyrophosphate (PRPP): vital precursor for all
nucleotide synthesis
