Glycogen Catabolism

Glycogen

Glycogen Catabolism

Fundamentals:

• Glycogen + Pi <--> Glucose 1-phosphate + Glycogen(-1)
  • Glycogen Phosphorylase - Phosphorolysis
• Glucose 1-phosphate <--> Glucose 6-phosphate
  • Phosphoglucomutase
    • Glucose 6-phosphate G6P--> Glycolysis
• 3XGlucose (From Branched) <--> Glycogen-Glucose (Remaining Branched)
  • Glycogen Transferase
• Glycogen-Glucose (Remaining Branched) <--> Glucose + Glycogen (Until Branch Next Recognized)
  • alpha-1,6Glucosidase - debranching enzyme
    • Glucose --> Glucose 6-phosphate G6P- Glycolysis

Specifics:

• There are no transporters for glucose 1-phosphate

Pertinent Hormones:

• Glucagon
• Epinephrine

Terminology:

• Phosphorolysis: cleavage of a bond by the addition of Orthophosphate/Pi