G6P Dehydrogenase Deficiency

ConditionsDiseases List

Enyzme that creates NADPH

G6P Dehydrogenase Deficiency

• Rare
  • Genetic mutation found in African, Asian, Mediterranean
    • 400 million WW

Fundamentals:

• Hemolytic Anemia caused by medications: = PROBLEM
  • Antimalarials-Quinones
  • Antipyretics
  • Sulfa antibiotics

Pathogenesis:

Genetics:

• Genetic predisposition for weak production of NADPH

Biochemistry:

• However the hemolytic anemia changes body chemistry to NEED NADPH = PROBLEM
  • Insufficient Production NADPH, Overuse NADPH
    • IOW - High demand, Low supply

Salient Chemicals:

• Glutathione

Salient Metabolic Pathways:

• Pentose Phosphate Pathway