Fatty Acid Synthesis
Lipid Synthesis Reguation
Hormonal system
Diet regulation
Fed
Storage as trigs
Excess GLC and AAs go to storage
INC Insulin – ANA hormone
Genetics: INC activity
Malic Enz – FA synth
G6P dehy – PPP
6Pate – PPP
DEC activity hormone sensitive lipase – FA oxidation
Fasting
GLC DEC
Insulin DEC
INC glucagon – CAT hormone
INC activity of hormone sensistive lipase – FA oxidation
Perlipin A – remember? – FA oxidation
INC breakdown of trigs -> FA and Glycerol
Liver
INH AcCoA carboxylase - FA synth DEC
Generation ketone bodies
Phosphorylation
INH AMP activated protein kinase
