Endocrine

InterSigTrans

Cell secretes a hormone that travels the blood stream to reach target cell/receptor

Signal delivered by blood
Large scale control
Dilute
Long duration
InterSigTrans
Quick/local shortlived
Signal is not into secreted into the blood - Local mediators
Concentrations tend to be high
Low affinity

Concepts:

The shorter the distance the higher the concentrations, high Km, lower the affinity, shorter duration DEC Distance - DEC duration, DEC affinity, INC Km, INC conc, INC # tissue control Low distance (Autocrine, Synaptic/Juxtacrine, Paracrine, Endorine) High Distance