Adenylate Cyclase (AC)

Enzymes - Enzymes Clinical Significance
Signal Transduction

Lyase that triggers the cyclization of cAMP

• Lyases

Function/Purpose:

• ATP -(AC)-> cAMP
• Converts extracellular signals into intracellular signals

Fundamentals:

• cAMP cascade is turned off by cAMP Phosphodiesterase
• Epinephrine binding to receptor increases the cyclizing

Mechanism:

beta-Adrenergic Receptor/G Protein Function

• beta adrenergic signaling
  • Galpha binds to surface of where betagamma dimer was in its GDP form
• Galpha(s) is activated
  • Increases the rate of reaction

AC Function

• Binding of cAMP to regulatory chains releases the catalytic chains
• Activated PKA then phosphorylates Serine and Threonine residues on in many targets to alter their activity

Additional Information:

• Wikipedia