Peripheral

[[Membrane Proteins]]

==Proteins that are bound to the polar head groups of lipids==

=Peripheral Membrane Proteins=
====Fundamentals:====
*Can be influenced chemically
**Disrupted by adding salts
**Changing the pH of the membrane
====Types:====
*Prostaglandin H2 Synthase 1
''Function/Purpose''
*Converts arachodonic acid to prostaglandin H2
**Prostagalnding promotes inflammation and modulates gastric acid secretion
**Arachodonic acid is created by the hydrolysis of membrane lipids
''Mechanism''
*Arachodonic acid moves inside the hydrophilic core of the plasma membrane
**Between the polar heads
*Active site is inside the plasma membrane
''Clinical Applications''
*Asprin and ibuprofen block the channel and prevent the prostaglandin synthesis
**Reducing the inflammatory response
***HOW? Asprin donates a acetyl group to a serine residue to block the channel
====Additional Information:====