I&I

Inquiries and Ideas

LIFE IS SHORT. Secondly, by no means in this contemporary world can one Leonardo Da Vinci exist in such a complex, stratified and innovative areas of science. Inventions and ideas are just becomming too hard to do, impossible to do with our current scientific knowledge and communication with other fields (they are drifting a part). I guess that is why MIT is pushing towards "convergence," which by every right, they should, especially because of their scientific "power" - in fact I commend them. I hope they are listening or thinking of ways to do this so: MIT ASIDE.
So here are just some ideas I had been keeping as well as inquiries I have been meaning to get to but have been getting sidetracked - thats life.

INQUIRIES

• Fistula types
• Adenoma
• Rectal sheath and concept of muscles and tendons
  • Area of insertoin and etc
  • Peritoneum
  • Muscle
  • Fascia
• "trinity" of blood vessels: 2 veins and 1 artery concept
• Inguinal nerve
• Spermatic cord
• Peristalisis vs pressure from blood vessels
• What is the time allowed to keep the bowels out without drying
• What is the point of the diagram for LAB DATA in nursing charts (Partition symbol (>-<)and what each number means)
• What is the role of bilirubin in the Lap Chole and perforated gall bladder
• Is NaCl with ESU safe (electrolytes and electricity - cuase and effect, severity)
• Sutures:
  • Ethilon
  • Mersilene
  • Tevder
  • Maxon
  • PDO - is it like vicril
  • Look up PDSII
• Neosynephrine
• What is TOA
• Hemorrhagic stroke

Significance of Data

• Cbc/chem: Hct 24% (36-60)
• CBC/reticuloscyte: HCT 21% 172,500
• Multifocal spinal pain: PCV/TP
• http://emedicine.medscape.com/article/190115-overview - decubitus ulcers
• what is frozen section? - http://en.wikipedia.org/wiki/Frozen section procedure
• one would have the disease that Prozac, Xanax, or Klonopin treats
• http://www.alzinfo.org/alzheimers-treatment-cognitive.asp# - alzheimers
  • Alzheimers or dementia and caffine intake over time (good thing or bad?)
  • Link between caffine and alzeihmer, caffine supposedly reduces the risk for parkinson's - ttran6@mail.usf.edu
• http://www3.interscience.wiley.com/user/accessdenied?ID=122455604&Act=2138&Code=4717&Page=/cgi-bin/fulltext/122455604/PDFSTART - stem cells
• http://www.radiologyassistant.nl/en/ - radiology practice pictures
• is too much vitamin b12 bad? - general principle of too much of anything is = bad
  • ZipFiz 41k% daily value too much?
• phenylalanine - what are the reference values or nutritional values, because it IS an essential amino acid

(i did feel a little differently when taking PHE via in gum: felt better GENERALLY speaking even with the same lifestyle of 2-6hrs sleep and caffine overload)

• acetylcholine, http://www.fi.edu/learn/brain/proteins.html, derivaties, sources, links to emotion, pain

so being in constant pain (physically/emotionally) hurts memory due to the overproduction/overstimulation/desensitization of acetylcholine

• • is there a destruciton of receptors
  • is there competitive inhibitors
  • are there acetylcholinesterase
  • soy milk and egg yolk = sources
• B.A.R.T. test and breast cancer
• myristic acid
• why do smokers have more vital capacity - aaron is an asthmatic and an athlete but has the lowest pulmonary test, tidal volume, forced vital capacity was low
• drinking and women's cancer
• cognitive development in children of older fathers
• lime juice allowed to dry in fingers and the adhesive properties afterwards?
  • Skin + lime-OH (acid) --> skin (washed away the oils)
  • Allow the phosphate portion to interact in polar bonds with one another?
  • Used as a way to teach measurable effects of the intermolecular forces

How do amines affect the body - antibiotics
How do epoxides affect the body - CNS
Wormwood - methanol competeing with ethanol
Artificial Nails and association with infections
Silver catheters prevent foley - how to insert foleys Meatus and statblock
Alcohols killing clostridium --> authored by susan brown
Clavicide cleaning hands?
Petroleum and mechanism why they do infect with medical scrubs What is the mechanism
Lactobacillus acidophilus and its contradicitons for long term use and with prosthetic heart valves Lactinex compared to Activia the miligrams http://www.bd.com/ds/technicalCenter/productFaqs/FaqLactinex.asp - Lactinex
Blood thiner medicaitons and green vegies - Vitamin K counteracting with blood thinners Vitamin K is used for blood clotting activity
CRP and birth control - people with birth control have a higher CRP but over time is there a cellular mechanism that adapts the body to the CRP C-Reactive Proteins
Omega 3:6 1:1 in healthy countries 3:6 1:20 in non-healthy countries Differences in omega 3 and 6
Allocen phytochemicals
The huge purple nose and alcoholics
The time table for the formation of bone
Based on physics, why does it take more radiation to penetrate frozen items? If it is based on density, water is less dense but the ice's crystaline strucutre make it more prone to absorb the radiation compared to more dense water but in liquid form
The link of triglycerides to LDL and HDL so is it like the Lechatleir's priciniple?
210,000 Calories to Survive The Winter
Half of the worlds population is in cities
Helen Fischer - Rutgers http://www.helenfisher.com/about.html

Ideas

IDEAS:

• Wireless power, to be able to conduct power between fields without doing any harm.  Or wireless cable signals.

• Hydrogen peroxide being used in internal tissue http://www.ncbi.nlm.nih.gov/pubmed/3596956 NIH
  • Sure it signals the entry and exit points but is it doing more harm as an oxidant on the cellular level
  • Especially if not treated properly
  • WHat happens to tissue that exposed to hydrogen peroxide for long periods of time?
    • OHs deprotonate the crap out of the tissue?
    • Base catalyzed reactions of sugars
    • Proteins?
    • Nucleic acids?
    • Lipids?

• “Drano” for the body, passes stomach acid and reaches to large intestines to flush out system instead of a traditional colonic
  • What does a colonic do anyway?
  • Mechanical removal of intestinal normal flora
  • Effectiveness of treatment in the first place

• “Rape lo-jack”, chemicals in the sexual fluids “mark” the persons whom had intercourse with for a set period (1 month to year with half life of chem.)

• Lifetime hair removal and stimulant (reverse)

• Lindane = find a better last resort for head lice without the poisonous effects

• Concept with plants or babies, drugs during pregnancy = baby addict, plants absorbing things in environment
  • Why not use medications dissolved in solution to “water” the plants to see if they take in the medications, eventually, multiply generations to increase the concentration of medication – needs a way to stimulate the growth of plants within faster periods
  • Babies – identify foods that make the baby addict more prone to beneficial items instead of dependencies, foods that have phytochemicals and etc that would be able to treat this condition
    • Assumption that babies are really addicts to substances
      • Refute? - during the most growth is is possible for the body to tolerate and move beyond the dependency in such a young age
      • What are the impications of dependencies at a such a young age because the body at that age is very resilient to certain conditoins
  • http://www.time.com/time/health/article/0,8599,2020815,00.html

• AED’s and pregnancies, find something that would insulate the shock of the AED without harming the baby or medical personel working on the patient

• Controling blood loss by isolating sections to be blocked (being worked on and untouched) putting the isolated into their own circulatory system as necessary and the remainder into the normal circulatory system unless the heart is being worked on, then use a fake heart as part of the circulatory system.

• Ebola controlled by chitosan??

• Mechanism that removes the site with dirty stick to prevent bodily contamination.

• Fungus/bact stimulates the growth of cancer in chewing tobacco??
  • http://www.silverbulletenterprises.com/cancer%20and%20bacteria.htm Bacteria Causing Cancer

• Teraforming by using plant and fungus combination to allow plants to dominate any land it pleases

• Link between heart and headaches/migranes makes sense because the heart and headaches probably mean that parts of the brain was loosing oxygen debt. White matter and hypertension

• Link between the number of “friends” on social networks and dependency dysfunction.

• Calculating the density of chlorophyll a and chlorophyll b

• Revolutionize the way of TLC - thin layer chromatography find other ways of using TLC
  • Problems with test tube recrystallization – lab technique

• Surgical way to relieve people that can only breath out of one nostril

• How do gymnasts women delay their first period if it is true?  - "Caloric shorfalls could also trigger physiological problems such as lower levels of estrogen in women and testosterone in men, both hormones have protective effects" - premise is that some athletes are not eating enough to effset what they burn when they exercise

• Cheap fire estinguisher

• Better headache treatment (vaccine)

• Period symptoms suppressor but not necessarily the period

• “TAN” inoculations (MSH)

• Micromachine tags to prevent rapes/kidnappins machine implant self during exch of fluids and receiver locates the individual

• A textbook that is all business with example and links for those that need further explanation.  Explains all vocab in intro

• A way to test if a person is chemically imbalanced

• Surgery (appendage): using neurotransmitters to fool the brain into thinking its colder as to limit circulation in appendages, then using the opposite to fool the brain into thinking its hotter to provide increased O2 in appendages

• Develop a standardized system of Nonverbal communication during surgery (brain being able to be wired for communicatoins like in paralyzed people), keyboards that are sterile for typing, communicators used to seal mouths of surgeons to orchestrate the team while team has sterile earpieces

• Amputation that does not keep the severed nerves activated after the procedure
  • Spray to knock of the depolarization to ensure the ends of the nerves are permanently depolarized
  • Chemical that terminate the ion channels of the section of nerve needing treatment?

• AIDS/HIV a hormone possibly or produces an exotoxin that acts like a hormone?

• Heartburn = drinking while inhaling --> feels like 20 thousand burps that had built up and won't come out, build up pressure of gases

• Take the OP's occupations and classify them to white collar, blue collar, professional as an experiment

 

• If a .1kg apple exerts 1.6x10^(-25) when falling on the earth, is it possible that the sum of all the collective earthly acceleration every sum up to something greater that can change the earth's acceleration?
• Finding an effective way to determine the fisherman's rowe (eggs from herring) are the most mature
• Developing a way to integrate technology and prospective methods of determining what a person eats to better accurately measure the nutritional status
• Pairing distillation processes of a water treatment facility with the cooling process of industires making sure that the pipes used to cool do not have any potential in infiltrating the water supply it is heating up (mutualistic architecture)
• underground vault and storage, morton salt, ALS, ansul, jocund,
• Can gravity be proportional to a things mass if so everthing has gravity supported by the electron theory where the nucleus has gravity over electrons
  • Something in quantum mechanics and gravity
• Resume card - Monster.com/even applicable to built in smart phone technologies of turning the cell phone into a credit card
  • Have a platinum account where the account member pays a yearly fee of $5-11 per year
  • they receive a card with their account #
  • This account # can be used when applying for jobs without the need for paper and they can instantly just schedule an appointment (possible sd card build in or a card like the us army has) for an interview
  • When HR accesses one's resume on this account # they have their contact information so they can call to confirm an interview no call means no interview
  • Card
  • Picture
  • Contact info
  • Resume stuff inside the barcode or sd card of the card or information build into the smart phone
  • Companies can post their positions and through monster.com people can apply for these positions.
  • Charge companies a fee to be able to access the resume bank depeding on the size of company --> transition to driver's liscence being able to be scanned into the (legislation and lobbying needed)
    • Major business model comes from the fees of the company - fee would have to be determined by the research of the savings if implemented vs HR manhours, paper, time, etc - can reduce the number of HR or make HR more efficient in processing applicants
  • (Research costs for paper usage and decreased inefficiency with filling out application )
  • Reschedule interview and etc
  • Companies need to provide standards in open positions so that there is a clear and efficienct way of searching
  • Similar to usa.gov but private
  • Smaller companies can easily look at a resume via account # just reschedule a day for interview or interview the perosn on the spot if they qualify
  • Have the fee variable to a determined mathematical equation derived from research of cost effectiveness
    • Meaning it should be function of manpower, revenue, and calculated cost savings - meaning that small companies would get a higher discount compared to larger corporations
      • Spurs competition due to a possible INC in small businesses and ease of the application process
      • Since smaller businesses pay a smaller price to advertise open positions than corporations, many small businesses can flood the job market
      • Obviously it is still up to the applicant to sort out (requires some technical programing to assess the most efficient means) but this can level the playing field where not only the best and brightest goes to large corporations but even quality small businesses can have a chance to intice the best and brightest

• Dirty sticks procecdure- research transmitability of blood and pathogens and etc
  • Double tirniquites, cooling and leeches are followed by usual meds antivirals and etc
• If there is a selective media for bacteria, the im sure there is a selective media for human cells - NO?
  • INQUIRE - components necessary for cell life depending on cell type
  • This can lead to better wound treatments
  • How to better band aids and
  • Dermatological applications
• New sterilization/disinfecting or etc - Using a relatively low humidity (low water activity than 0.91), high temp and high pressure
  • Or using air jets to blow away the condensation from current sterilizers so that there is 0% strikethrough contamination
    • Using a composite/plastic/acrylic/ceramic barrier that raises to shield the trays and then use the jets to blast condensation and residual water unevaporated around autoclaves
      • Will just adjust the lenght of an autoclave by a few inches but will require a mechanism/motor to lift&descend barier
• Study on birth control pills and its effects on women - quantitative and qualitiative

• Reverse positivism - in that a negative inverse may yield a better result. Taking the toxic enatiomers that may yield better positive results - OCHEM

• Higher temp = higher vapor pressure = shorter people?
  • Cellular perspective on this
  • Higher temp = ? genetic response to adapt muchlike an adaptation to higher altitudes
    • If there is a link this can open a new perspective on environmental biology
      • High altitude = ? on a cellular level
      • High temp = ? on a cellular level

• Putting a block into the lacrimal canals to aid a boxer's airway from the fluids
  • What is the mechanism behind the lacrimal canals?
  • Inhibition that is most effective?
  • Either needs a short half life or a shot to counter the effects after treatment

• What to use to make an alternative to latex gloves

• What are the exceptions to the genetic code? Is it possible for people to finally mutate out of this code given that there are billions of people? Is it possible for people to start using 4 letter codons? Is it possible for people to use different codons for different amino acids? - the code was worked out 50 years ago, could their assumption be wrong?

• What is the link btwn the kinetics and thermodynamics of spontaneity?
  • Thermodynamics is dictated by Gibbs EQTN (derivative concepts) and occurs without ENG input
    • Gibbs deals with the amount of free energy to do work
  • Kinetics is only dictated by the aENG and collisions
    • Collisions to overcome the aENG
  • Why cant free ENG and aENG be linked?
    • Will it have enough dG to overcome the aENG - that should be the unifying concept btwn the two

• Are there any ferromagnetic surgical instruments designed to become magnetized to remove metallic debris from tissue?

• Avaguard and reliability for sanitizing the hands VS 5 minute surgical scrub
  • Full Blown - analyze the bact in hands
    • What is the req NORMAL # colonies needed
  • Try to get peds and elderly immuno, diabetiec and etc
    • Compare it with all the hand scrubs
  • Find a petri dish that is 7-12 in in diameter to directly innoculate the hand on the dish

• Finding a New Antibiotic
  • Why not combine different R groups together or have multiple ended
    • It is because of there is ONLY ONE R GROUP!
  • What about utilizing/building a molecule that mimics the triglyceride fatty acid composition
    • Glycerol and ester linked medications? So that each fatty acid contains an antibiotic
  • What about changing the N to become a P (same family)
    • Like a phospholactam?
      • Or instead of changing the N to become a P in the lactam ring why not add the P in the amine? - would it lose it's reactivity? But maybe it could hold another carboxyl R group instead of an H

• In terms of clinical chem, why not taking constant samples of pt's individual serum and keeping it or if possible to record its constituents to have a baseline data of the individual So if something pathologic appears, they can refer to previous data.

• However if the person is identified to have genetic conditions, then a normal should can also be used to compare with the individual and they have data over time

• Is there a way to record the components of biological samples

• Specifically if there is some technology that keeps the recipe of the biological fluid like a finger print

• In terms of the link of Chron's disease (m. avium - paratuberculosis)

WHY NOT LOOK AT WAYS TO IDENTIFY THE CATTLE that are known to cause the problem instead of just altering the product, why not target the source INSTEAD OF CHANGING THE INDUSTRY PRACTICES?

• • treat grass that is treated with AA that is taken up so that when hydrolyzed by stomach acids will kill mycobact
  • research m. avium and pathogenicity of paratuberculosis
    • is there a way to test cattle? in a cheap manner

• Sociology of Condoms:
  • Aside on the comparison on condoms sold behind the counter and contemporary placement
  • People were embarassed to have to buy behind the counter than now

• Volume expanding IV fluids for endotoxin treatments
  • Dextrans? since endotox DEC blood volume

• System to Refine Malpractice

[1] Determining a system to refine standards of error and negligence, as well as finding a way to expidite resolution of a claim.

• • What about a cap system that is based on the severity and function - meaning that if the cases are stratified into similar in disfiguring/loss of function group caps with the more severe obviously having a higher cap and common cases having a reasonalbe/practical cap.

• NonNewtonian Fluid and Puncture Proof Gear(Dirty Stick Sleves/Gloves for all applications (cops to med))/Bulletproof Vests for

[2] [3]

• Develop a cheap and easier way to detect CK-BB in normal serum

• Surgical Fluids and Chances of Infection:
  • It has been said to "ALWAYS HAVE SALINE AT THE START OF CASE (and other liquids)" - however, just found out about pseudomonas growing in sterile waters. open 2-5 minutes before? instead of letting it sit to reduce the number of infections? must inquire.
  • Determine a way to study the affects of sterile water openend and its relation to volume, time, CFUs and etc

• Developing an Anaerobic Room which can transition into a Marine Room (however much harder to accomplish)
  • Develop with NASA as a way to train astronauts in an environment that is devoid of gases needed to sustain human life
  • A room that essentially a large GasPak chamber
    • Holding room that transitions between aerobic and anaerobic areas building up the equilibrium of gases
    • Inquire with an engineer to determine the specifications
    • Operators require suits that prevent contamination throughout the entire body especially protecting the eyes
      • Space suit-like
      • Incorporate diving technology respirators, so like a giant bubble covering one's head and a suit to sustain cooling the human body while not contaminating and making work impossible

• Why not take samples of lymph nodes like any other type of blood vessel
  • Inquire about gross and micro anatomy of lymph nodes
    • This hopefully can be used to isolate bacteria
    • However there is a limit with current anaerobic practices

• Determine a cause to SIDs and other conditions by isolating organs and labs between normal and those afflicted
  • Bacteria?

• Determine a protocol for assisted suicide

• UNECOM's Flourescence Ideas:
  • comming soon

• "Creating an artificial cell" still need to find the University
  • Using temperatures with the vibrations to simulate real world Brownian motion coupled with random changes in temperatures to create scientific 'artificial life = cell'.

• The Dead Zone and Possible Cancer Therapy?
• "The Dead Zone: Too Much Respiration
  • Some marine organisms require such a high rate ofcellular respiration,and therefore so much molecular oxygen, that the oxygen concentration in the water is decreased to a level that is too low to sustain the respiration ofother organisms.One such hypoxic (low levels ofoxygen) zone is in the northern GulfofMexico,offthe coast ofLouisiana where the Mississippi River flows into the Gulf(Figure 19.18). The Mississippi is extremely nutrient rich due to agricultural runoff; so plant microorganisms, called phytoplankton, proliferate so robustly that they exceed theamount that can be consumed by other members ofthe food chain.When the phytoplankton die,they sink to the bottom and are consumed by aerobic bacteria. The aerobic bacteria thrive to such a degree that other bottom-dwelling organisms, such as shrimp and crabs,cannot obtain enough O2to survive.The term “dead zone” refers to the inability ofthis area to support fisheries.
  • (Tymoczko, John L.. Biochemistry: A Short Course. W.H. Freeman/CourseSmart, 01/09/2009. p. 312).
  • Look at the genome of these bacteria and try to trigger a way to place this inside to the strictly cancerous cells.
    • The high rate or respiration + high rate of cell division = live by sword, die by sword
      • High division = chances of future cells to incorporate genome
      • The cells will not be able to keep up with the demands of the cell and die?
        • Mechanisms for apoptosis - ?INQUIRE?
    • Possible side effect, the cells run rampant.
  • Perspective of glutony - the cell will not be able to keep up with the demands of high division and high respiration.
  • They simply have too much on their plate as a cell

• UNECOM's Flourescence

• Elusiveness of Anaerobes:
  • In anaerobic respiration in some organisms, chemicals other than oxygen are used as the final electron acceptor in an electron-transport chain. Because none of these electron acceptors are as electropositive as O2, not as much energy is released and consequently not as much ATP is generated.
    • Find the distinct chemicals
    • Incorporate into new anaerobic media
      • Antibiotics can be used as weapons against anaerobes - however we need to find out how they behave
        • A way to starve anaerobics
      • The hard part is studying how anaerobes behave

• Dismutase Half Life in Varying Regions of the World
  • Nationalities
  • Ways of explaining differences:
    • Social cultures - stress
    • Life style - foods, exercise

• Cleaning house of scientic clutter: Why not revisiting old scientific "facts" and reproducing them with today's technology
  • Does the data support it
  • Compiling the most recent with the oldest
  • As an alternative instead of basing potentially correct science on something that is fundamentally wrong

• Nanoengineering:
  • Rotational catalysis creates a proton gradient is there other things this can be coupled to to?
    • Determine the genomic sequence that programs a cell to make ATP synthases
    • Are there dysfunctions to this rotational catalysis?
      • Leading to dysfunctions or diseases - furthering our understanding of some diseases - hopefully towards something substantial aside from more theory and text books
  • Does this need some sort of upkeep
  • What is the stability of this?
    • Is there a way to measure any friction?
      • Is there a way to measure the forces on the cell membrane?
        • What is the most a cell membrane can witstand in terms of forces?
          • Is it possible to shake the cell membrane to disrupt its semipermeability?
    • Is there any way to disrupt this pump like throwing a long into a motor to jam it mechanically?
  • Anti cancer nanoengineering: after knowing the sequence, is there a way to create a rotational catalysis that destroys a cell?
    • 1)Use the programing in place in a phage = phage therapy for cancer cells
    • 2)Use cancer sensing bacteria to invade cells with these rotational catalysis with proteins that "chop" the membranes of cancerous cells on their cell surface
      • Since bacteria only invade cancer cells, it is self limiting and would only "attack" cancer cells
    • 3)Simply disruct the tonicity of cancer cells
      • Take genome to create rotational catalysis in mass all over the cell membrane
  • Evolution ramifications of ATP synthase is there a link to flagellar motion? because if you attach a protein to it and it rotates = motility!
    • Which came first? ATP synthase or reverse engineering of flagellar motion?

• Cinnamon

• NHIF - I&I part 2