Glycolysis Regulation

Glucose, Glycolysis

1)(GLC) into (G6P) - Hexokinase

• Glucose into Glucose 6-phosphate

Negative Effectors - anabolism of GLC or breakdown of glycogen

• G6P

2)(G6P) into (F1,6BP) - Phosphofructokinase (PFK)

• Fructose 6-phosphate into Fructose 1,6-bisphosphate

Negative Effectors - intermediates for TCA are high = energy rich

• ATP
• Citrate

Positive Effectors - intermediates for TCA are low = energy poor

• ADP
• AMP

3)PEP into Pyruvate - Pyruvate Kinase

• Phosphoenolpyruvate into Pyruvic Acid

Negative Effectors - pyruvate concetrations are high

• ATP
• F6P

Concepts:

• Allosteric Enzymes - Enzymes
• Effectors - Enzymes