Glycolysis/EMP

Cellular Metabolism - CH15
Cell Metabolism - Gluconeogenesis

Taking glucose and preparing it to be used in the cell

• Triggered by Glucose (GLC)

Glycolysis/Embden Meyerhof Pathway (EMP)

GLC + 2Pi + 2ADP + 2NAD --> 2Pyruvate + 2ATP + 2NADH + 2H + 2H2O

• -96kJ mol

Regulation:

• Glycolysis Regulation

Function/Purpose:

• Turning glucose into three similar and phosphorylated molecules to be converted into pyruvate

Fundamentals:

• Substrate level phosphorylation

Products

• Pyruvate

Stages:

• Stage1: conversion of glucose into fructose 1,6-bisphosphate
• Stage2: cleavage of fructose 1,6-bisphosphate
• Stage3: ATP is harvested when carbon fragments are oxidized to pyruvate

Steps:

• Glycolysis Steps

Saleint Chemicals:

• Glucose
• Fructose
• Galactose
• Mannose

LOC:

Micro Organelles:

• Cytoplasm

Macro Organs:

• Blood Cells
  • Red Blood Cells
    • WHY? No mitochondria
  • Leukocytes
• Eye: Cornea, Lens, parts of the Retina
  • WHY? No mitochondria
• Kidney Medulla
• Testis
• White Muscle Fibers

Salient Diseases:

• Diabetes

Concepts:

• Phosphorylation
• Organelles
• Movement Across CM - Permeability

Additional Information:

• Manipulative Presentation - Oh, I Went There
• Wikipedia
• Glycolysis