Cell Wall Synthesis

• Peptidoglycan

Creating cell walls of bacteria

Cell Wall Synthesis

Mechanism:

Fundamentals:

• Intracellular pressure in cells is enormus
  • Cells walls are bolstered by Peptidoglycan to stabilize the cell
• Three Stages:
  • Synthesis of Precursors
  • Synthesis of Linear Peptidoglycal Strands
  • Crosslinking

Synthesis of Precursors:

• NAG-Uridine Diphosphate -(Phosphoenolpyruvate (PEP) and Enzyme)-> NAM-UDP
  • Isomerism of NAG-UPD to NAM-UDP w/ help of PEP and enzyme

Prevention Through Fosfomycin

• NAM-UDP -(ATP and Enzymes)-> NAM-UDP-(AA)-AELAA
  • Creation of the Park Nucleotide
    • AA sequence attached to NAM-UDP: L-ala-D-glu-L-lys-D-ala-D-ala

Prevention Through Penicillin
Prevention Through Cycloserine
Prevention Through Vancomycin

• (AA)-NAM-UDP --> (AA)-NAM-DP-C55Terp
  • Lipid I creation: exchanging Uridine for C55Terp - Membrane Bound Carrier
• (AA)-NAM-DP-C55Terp --> NAG-(AA)-NAM-DP-C55Terp

Prevention Through Moenomycin

• • Lipid II creation: attaching NAG from the Lipid I
• Transported out of the membrane
• Creates the core strands of the peptidoglycan

Types:

Salient Examples:

Concepts:

Terminology:

Additional Information:=

• http://www.chem.qmul.ac.uk/iupac/misc/glycp.html Nomenclature