Tuesday, August 13, 2013

Fosfomycin

Medications - Antibiotics

Inactivates UDP-N- actetylglucosamine-3-enolpyruvyltransferase/MurA to prevent the formation of NAM-UDP

  • Inhibits enzyme that adds PEP (phosphoenolpyruvate) to the 3'-hydroxyl group of NAG (UDP-N-acetylglucosamine)
  • PEP analog that inhibits MurA
    • Alkylating an active site cysteine residue within the protein active site.
  • Fosfomycin is used clinically in the treatment of urinary tract infections, administered as a single oral megadose
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