Thioether Causes cross linking of DNA signaling apoptosis
Mustard Gases
Fundamentals:
- Alkylating agent
- Stabilizes DNA-DNA leading to apoptosis
- Toxic
LOC:
- ?
Mechanism:
- Intermolecular beta attack to form an episulfonium salt S(+)Cl(-)
- Cl is a good leaving group
- Sulfur epoxide is opened by a nucleophilic attack of DNA
- Occurs bilaterally
