7TM

Signal Transduction - Cell Surface Receptor

Initiate signal tranduction through changes in receptor's tertiary structure, coupled to G Proteins

G Protein

Seven Transmembrane-helix (7TM)/G-protein-coupled receptors (GPCRs)/G-protein Linked Receptor/Serpentine Receptor/Heptahelical Receptors

Function/Purpose:

• Accepts the ligand to change conformation of the receptor which affects G Proteins
• Hormone action, hormone secretion, neurotransmission, chemotaxis, exocytosis, blood pressure contro, embryogenesis, cell growth/differenciation, development, smell, taste, vision, viral infection

Fundamentals:

beta-Adrenergic Receptor Function

• Ligand binds to create a conformational change
• This conformational change affects a G Protein

Anatomy/Components:

Structure:

• N - Ligand binding site
• C - Cytoplasmic loops

Types of Ligands:

• Ions
• Odorants and Pheremones
• Small molecules
• Proteins
  • Cholecystokinin (CCK)/Gastrin
• Hormones
  • Lipid
    • Prostoglandins
  • Monoamine Neurotransmitter
    • Tryptamines - Seratonin
    • Catecholamine - Epinephrine
  • Non Steroid
    • Glucagon

Types of Receptors:

• beta-Adrenergic Receptor
• CCK Receptor

Types of Effector Proteins:

Types of Secondary Messengers:

• cAMP
• IP3

Concepts:

Terminology:

• Ligand
• Tertiary Structure
• Effector Proteins - Signal Transduction

Additional Information:

• Wikipedia